MODULATION OF RAB7A-MEDIATED GROWTH FACTOR RECEPTOR TRAFFICKING INHIBITS ISLET BETA CELL APOPTOSIS AND AUTOPHAGY UNDER CONDITIONS OF METABOLIC STRESS

Abstract Regenerative medicine approaches to enhancing beta cell growth and survival represent potential treatments for diabetes.It is known that growth factors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with type 2 diabetes the destructive effects of metabolic stress predominate and beta cell death or dysfu

The paper presents the results of a study of cyanobacteria and green algae assemblages occurring in various tundra types determined on the basis of mosses and vascular plants and habitat conditions.The research was carried out during summer in the years 2009-2013 on the north sea-coast of Hornsund fjord (West Spitsbergen, Svalbard Archipelago).58 s

Chum salmon is a widely spread species on the continental coast of the Okhotsk Sea presented Rear View Mirror Accessory Couple Card exclusively by typical anadromous phenotype.Abundance of the runs is well correlated with length of the spawning rivers, whereas dynamics of the runs is determined by variations of climate conditions and press of comme

Introduction: Universities play a key role in creating a knowledge-based society and its sustainable development.Strategic planning by strategically analyses internal and external environments of the organization, forecast its future, identifying its strategic direction, and strengthening organizational structures, processes, and outcomes, creates